Triangesinenolides A-C: Trimeric Phthalides with Anti-Renal Fibrosis Potential from Angelica sinensis
Hang Lv1, Yu Mu1, Bixuan Cao1
1Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, People's Republic of China.
Abstract:
Trimeric phthalides in nature are rarely reported. This research successfully isolated three novel trimeric phthalides, triangesinenolides A-C (1-3), from Angelica sinensis. These compounds, derived from Z-ligustilide via diverse linkage patterns, display intricate polycyclic skeletons. Their structures were confirmed by spectroscopic and crystallographic analyses. Unlike previously identified trimeric phthalides, triangesinenolide C (3) is the first trimeric phthalide synthesized via [2 + 2]/[4 + 2] cycloaddition. In vitro assays evaluated the anti-renal fibrosis activity of trimeric phthalides for the first time.
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