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Synthetic versus conventional MRI for ring-enhancing brain lesions: A pre- and post-contrast comparison
Sanket Dash1, Sameer Vyas1, Nidhi Bhardwaj2
1Division of Neuroimaging and Interventional Neuroradiology, Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.
The Neuroradiology Journal
|February 27, 2025
Summary
Synthetic MRI offers comparable diagnostic image quality for brain lesions, with acceptable artifact rates. Careful interpretation is needed, especially for lesion enhancement patterns.
Area of Science:
- Radiology
- Medical Imaging
- Artificial Intelligence in Medicine
Background:
- Synthetic MRI reconstructs multiple contrasts from one acquisition, potentially reducing scan time.
- This technology aims to improve efficiency in neuroimaging procedures.
Purpose of the Study:
- To compare image quality of synthetic MRI (pre- and post-contrast) with conventional MRI.
- To evaluate synthetic MRI in patients with ring-enhancing brain lesions.
Main Methods:
- 50 patients with ring-enhancing brain lesions underwent TSE_MDME synthetic MRI and conventional MRI.
- Image quality assessed using a 4-point scale (grey-white matter differentiation, nucleus demarcation, sulci, SNR), artifacts, lesion conspicuity, and diagnostic ability.
Main Results:
- Synthetic MRI image quality was similar to conventional, except for FLAIR sequences.
- 70.7% agreement between synthetic and conventional images; Weighted Kappa = 0.043.
- Synthetic FLAIR had maximal artifacts (52%); 50% discordant enhancement patterns in post-contrast synthetic images. Diagnostic ability was comparable.
Conclusions:
- Synthetic MRI provides comparable diagnostic quality with acceptable artifacts for pre- and post-contrast sequences.
- Careful interpretation is advised, particularly when lesion enhancement patterns are critical for diagnosis.
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