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Hepatic Expression of Fibroblast Growth Factor 19 Significantly Correlates With Serum Bile Acids in Neonatal

Ola A Fouad1, Doaa F Zaghlol1, Dina M Sweed2

  • 1Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|February 27, 2025
PubMed

Insights

Hepatic fibroblast growth factor 19 (FGF19) is upregulated in neonatal cholestasis (NC). This increased FGF19 expression correlates with cholestasis severity and serum bile acid levels.

Area of Science:

  • Hepatology
  • Endocrinology
  • Pediatric Gastroenterology

Background:

  • Bile acids regulate their synthesis via ileal fibroblast growth factor 19 (FGF19).
  • This feedback loop is disrupted in cholestasis.
  • FGF19 is typically absent in healthy liver tissue.

Purpose of the Study:

  • To investigate hepatic FGF19 expression in neonatal cholestasis (NC).
  • To determine the relationship between hepatic FGF19 and serum bile acids in NC.
  • To assess the correlation of FGF19 expression with cholestasis severity.

Main Methods:

  • Immunohistochemical analysis of FGF19 in liver tissue from 41 NC patients.
  • Evaluation of FGF19 staining in hepatocytes, endothelial cells, bile ducts, and canaliculi.
  • Comparison with liver samples from children with Crigler-Najjar syndrome type-1 as controls.

Main Results:

  • Significantly higher hepatocyte, endothelial, and canalicular FGF19 expression in NC patients versus controls.
  • Positive correlation between serum bile acids and FGF19 expression in hepatocytes, endothelial cells, and bile ducts.
  • Hepatocyte FGF19 expression linked to elevated total bilirubin, direct bilirubin, and AST levels, indicating cholestasis severity.

Conclusions:

  • Hepatic FGF19 expression is significantly upregulated in neonatal cholestasis.
  • Increased FGF19 expression in the liver is associated with cholestasis severity and serum bile acid levels.
Abstract

Keywords:
FGF19bile acidscholestasisimmunohistochemistryliverneonatal

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