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The Dose-response of Blood Pressure Variability in Stroke and Coronary Heart Disease

Woro Riyadina1, Sulistyowati Tuminah1, Lely Indrawati1

  • 1Research Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.

Current Hypertension Reviews
|February 27, 2025
PubMed

Insights

Blood pressure variability (BPV) predicts vascular events like stroke and coronary heart disease (CHD). Controlling BPV is crucial for preventing these serious vascular conditions.

Area of Science:

  • Cardiovascular Science
  • Epidemiology
  • Public Health

Background:

  • Blood pressure variability (BPV) is recognized as a potential predictor of vascular events.
  • Elevated BPV can trigger target organ damage.

Purpose of the Study:

  • To determine the association between blood pressure variability (BPV) and the incidence of stroke and coronary heart disease (CHD).
  • Investigate BPV as a risk factor within the Bogor Cohort Study in Indonesia.

Main Methods:

  • A prospective cohort study involving 1649 Indonesian adults (aged ≥31 years) over six years.
  • Vascular events (stroke or CHD incidents) were monitored from 2011-2017 and 2012-2018.
  • Statistical analysis controlled for age, hypertension status, and lipid profile.

Main Results:

  • The incidence of vascular events was 12.4% over the six-year monitoring period.
  • Increased risk of vascular events, stroke, and CHD was observed with higher quintiles of systolic and diastolic BPV.
  • Specific thresholds for systolic BPV (≥12.10 mmHg) and diastolic BPV (≥7.31 mmHg) indicated significantly elevated risks (OR 2.3 and 1.7, respectively).

Conclusions:

  • Blood pressure variability (BPV) is an independent predictor of vascular events, including stroke and coronary heart disease (CHD).
  • Clinicians and the public should prioritize the control of BPV as a modifiable risk factor for cardiovascular diseases.

Keywords:
Blood pressure variabilityBogor cohort study.coronary heart diseasehypertensionnon-communicable diseasesstroke

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