Related Experiment Video
Updated: May 25, 2025
08:36
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
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Anlotinib-induced sick sinus syndrome: Two case reports
Cheng-Feng Fu1, Li-Fen Yang1, Lei Tian1
1Department of Oncology, Tongren People's Hospital, Tongren 554300, Guizhou Province, China.
World Journal of Clinical Cases
|February 27, 2025
Summary
Anlotinib treatment for non-small cell lung cancer may cause sick sinus syndrome (SSS). Close cardiac monitoring is essential for patients receiving anlotinib to detect and manage this potential side effect.
Area of Science:
- Oncology
- Cardiology
Background:
- Anlotinib is a tyrosine kinase inhibitor used in non-small cell lung cancer treatment.
- Sick sinus syndrome (SSS) is a cardiac arrhythmia affecting heart rate regulation.
Observation:
- Two non-small cell lung cancer patients developed SSS after anlotinib therapy.
- Symptoms included syncope and palpitations, confirmed by electrocardiogram.
Findings:
- Anlotinib use is associated with the induction of sick sinus syndrome.
- Treatment varied, including pacemaker implantation and medication cessation.
Implications:
- Cardiac monitoring is crucial for patients undergoing anlotinib treatment.
- Individualized management plans are necessary for anlotinib-induced SSS.
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