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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

462
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
462
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: May 25, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Erlotinib-Related Rash Resolved With Novel Treatment Using Systemic Intravenous Immunoglobulin and Stem Cells.

Iya A Agha1, Erika Malana2, Stanley Skopit2

  • 1Dermatology, New York Institute of Technology College of Osteopathic Medicine, New York, USA.

Cureus
|February 27, 2025
PubMed
Summary

A severe rash caused by EGFR inhibitors in lung cancer patients can be effectively treated. Intravenous immunoglobulin (IVIG) and stem cells resolved a refractory rash, allowing continued cancer treatment.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Epidermal growth factor receptor (EGFR) inhibitors are crucial in treating non-small-cell lung cancer (NSCLC).
Keywords:
drug rashdrug reactiondrug reaction treatmentegfr inhibitor-related rasherlotinibintravenous immunoglobulin (ivig)

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  • Drug-induced skin reactions, including papulopustular rashes, are common side effects of EGFR inhibitors.
  • Refractory cases significantly impact patient quality of life and treatment adherence.