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Updated: May 25, 2025
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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Intradialytic Hypotension Pathophysiology and Therapy Update: Review and Update
Elmukhtar Habas1, Amnna Rayani2, Aml Habas3
1Senior consultant, Hamad General Hospital, The Open Libyan University. Doha, Qatar.
Blood Pressure
|February 27, 2025
Summary
Intradialytic hypotension (IDH), a common complication in hemodialysis (HD), poses risks due to organ ischemia. Evidence for current IDH therapies is limited, highlighting the need for better prevention and management strategies.
Area of Science:
- Nephrology
- Critical Care Medicine
Background:
- Intradialytic hypotension (IDH) is the most frequent complication during hemodialysis (HD), impacting 10-12% of patients.
- IDH is associated with temporary ischemic stress in vital organs and increased patient mortality.
- The pathophysiology likely involves reduced effective blood volume and decreased plasma tonicity.
Purpose of the Study:
- To review current understanding of the pathophysiology of IDH.
- To discuss updates on the prevention and therapy of IDH.
- To identify gaps in knowledge and areas for future clinical research.
Main Methods:
- A comprehensive literature search was conducted.
- Databases searched include Scopus, EMBASE, PubMed, Google, and Google Scholar.
- Articles published within the last two decades were included.
Main Results:
- The pathophysiology of IDH remains ambiguous and unclear.
- Evidence supporting the effectiveness of current IDH therapies and interventions is limited.
- Optimizing dialysis prescriptions may help reduce IDH risk.
Conclusions:
- Further clinical research is essential to address the ambiguities in IDH pathophysiology.
- Developing effective prevention and management strategies for IDH is crucial.
- Limited evidence necessitates a focus on ideal IDH prevention over management.
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