Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nano-engineering the titanium-tissue interface: a 15 year perspective on bio-functionalization and surface innovation.

Nanoscale advances·2026

Same author

Efficiency Enhancement and Transparency Adaption of Bladed PM6:Y6 Solar Cells Doped with Binary Lanthanide (Eu<sup>3+</sup>/Sm<sup>3+</sup>)-Induced Polymeric Nanoaggregates.

ACS applied materials & interfaces·2026

Same author

Eu<sup>3+</sup> Complex-Protein Co-Crystals as Smart Sensors of Biologically Relevant Cations in Blood.

Materials (Basel, Switzerland)·2026

Same author

Modular Europium-Based Nanosensors for the Detection of Sodium and Potassium Ions.

ACS omega·2026

Same author

Electrosprayed Magnetic Poly(butyl methacrylate-<i>co</i>-(2-dimethylaminoethyl) methacrylate-<i>co</i>-methyl methacrylate)/Iron Oxide Microparticles for Efficient Curcumin Delivery.

ACS omega·2026

Same author

Bacterial adhesion and erythrocyte integrity on polycaprolactone nanowire surfaces.

RSC advances·2025

Same journal

A DLP-Printed 3D Bioceramplug Fabricated Using a Photocurable Negative Thermo-Responsive Bioceramic Slurry for Cranial Burr-Hole Repair.

ACS biomaterials science & engineering·2026

Same journal

A Microenvironment-Driven Peptide Nanoplatform Enhances Ferroptosis and Antiangiogenic Activity for Triple-Negative Breast Cancer Therapy.

ACS biomaterials science & engineering·2026

Same journal

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026

Same journal

Biomimetic 3D-Printed Resorbable Extracellular Matrix-Guided Bone Regeneration Membrane Based on a Gelatin Methacrylate/Alginate-Hydroxyapatite Composite for Maxillofacial Surgery.

ACS biomaterials science & engineering·2026

Same journal

Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin-Tazobactam.

ACS biomaterials science & engineering·2026

Same journal

Retinoic Acid-Functionalized Chitosan Polycationic Conjugates for Integrated Melanoma Therapy and Antibacterial Infection Control.

ACS biomaterials science & engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility.

Ramesh Singh¹, Liszt Y C Madruga¹, Aniruddha Savargaonkar²

¹Department of Bioengineering, College of Engineering and Computing, George Mason University, Fairfax, Virginia 22030, United States.

ACS Biomaterials Science & Engineering

|February 27, 2025

Summary

This summary is machine-generated.

Combining titania nanotubes (TiNTs) with Tanfloc (TAN) improves surface properties for biomedical uses. The modified TiNT-TAN surfaces enhance stem cell growth and control blood interactions, showing great potential for medical applications.

Keywords:

medical implants platelet activation protein adsorption surface functionalization titania nanotube

More Related Videos

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

Related Experiment Videos

Last Updated: Jul 5, 2026

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

Area of Science:

Biomaterials Science
Surface Chemistry
Regenerative Medicine

Background:

Titania nanotubes (TiNTs) are promising for biomedical applications but require surface modification to improve biocompatibility.
Tanfloc (TAN), a polyphenolic tannin derivative, offers unique functional groups for surface interactions.

Purpose of the Study:

To investigate the synergistic effects of combining TiNTs with TAN for enhanced surface properties.
To evaluate the interactions of blood components and adipose-derived stem cells (ADSCs) with TAN-functionalized TiNT surfaces (TiNT-TAN).

Main Methods:

Covalent functionalization of TiNTs with TAN.
Analysis of protein adsorption, platelet adhesion, and activation using fluorescence and scanning electron microscopy (SEM).
Assessment of ADSC viability, attachment, proliferation, and cytotoxicity on TiNT-TAN surfaces.

Main Results:

TiNT-TAN surfaces demonstrated controlled protein adsorption and reduced platelet adhesion and activation.
The modified surfaces supported ADSC viability, attachment, and growth without cytotoxic effects.
TAN conjugation significantly increased ADSC proliferation rates compared to unmodified TiNTs (p < 0.0001).

Conclusions:

TiNT-TAN functionalization enhances surface properties for biomedical applications by modulating blood-material interactions.
The enhanced biocompatibility and promotion of stem cell proliferation make TiNT-TAN a promising material for regenerative medicine.