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Gymnopeptides C and D, Highly N-Methylated Fungal Cyclopeptides
Márton Weber1, Miklós Dékány1, Andrea Nedves Nagyné2,3
1Spectroscopic Research, Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary.
Abstract:
An in-depth chemical study of the fungus Gymnopus fusipes led to the discovery of two new cyclooctadecapeptides, gymnopeptides C and D, besides the known gymnopeptides A and B. Spectroscopic studies, as well as Marfey's analysis, and molecular modeling studies revealed the characteristic structural features of these cyclopeptides. Gymnopeptides A-D demonstrated antiproliferative activity on the A375 human cancer cell line, induced apoptosis by upregulation of caspase-3 activity, and acted as a suppressor of cell migration.
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