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Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Updated: May 25, 2025

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
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Combining experiment and prediction to explore surface chemistry and dissolution.

Andrew G P Maloney1

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Understanding crystal structures is key for pharmaceutical development. This study links solid form properties to dissolution behavior using analytical and computational methods.

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Area of Science:

  • Solid-state chemistry
  • Crystallography
  • Pharmaceutical sciences

Background:

  • Crystal structures are crucial for pharmaceutical product development.
  • Understanding crystal properties aids in predicting manufacturing and in vivo behavior.
  • Solid forms significantly influence a drug's performance.

Purpose of the Study:

  • To investigate the relationship between the properties of different solid forms of a biologically active molecule and its dissolution behavior.
  • To demonstrate the utility of combining analytical and computational methods for characterizing solid forms.
  • To provide insights into solid-state factors affecting drug dissolution.

Main Methods:

  • Utilized a range of analytical techniques to characterize the solid forms.
  • Employed computational analysis of crystal surfaces.
  • Investigated three distinct solid forms of a biologically active compound.

Main Results:

  • Established a clear link between specific solid form properties and the dissolution rate of the molecule.
  • Demonstrated how surface characteristics influence dissolution.
  • Provided a comprehensive analysis of structure-property-dissolution relationships.

Conclusions:

  • The study successfully correlated solid form properties with dissolution behavior.
  • Analytical and computational approaches are effective for understanding drug performance.
  • This research contributes to the rational design of pharmaceuticals with improved characteristics.