Biological potential and therapeutic effectiveness with diverse signaling pathways of phyto-product chicoric acid: a
Muhammad Muzammil Nazir1, Iqra Farzeen1, Saima Zafar1
1Department of Zoology, Government College University, Allama Iqbal Road, Faisalabad, 38000, Pakistan.
Abstract:
Chicoric acid (CA), a polyphenolic compound found in chicory (Cichorium intybus), shows potential for the management of a number of diseases due to its antioxidant, anticancer, anti-inflammatory, and insulin-sensitizing properties. Chicory, a perennial member of Asteraceae family, is undoubtedly an underestimated vegetable. Currently, its primary usage is concentrated in India, Greece, Italy, and Poland. This review will concentrate on the potential of chicoric acid in different diseases through a study of the literature and in silico research. A comprehensive search of the literature was conducted using specialized and dedicated search engines. Chicoric acid has an impact on several disease types reported in vitro and in vivo. Chicoric acid has surfaced as a promising neuroprotective agent, anticancer, anti-inflammatory, antidiabetics, and antimicrobial exhibiting a broad range of actions that contribute to health and function. Bioactive compound effects on diseases are examined using network pharmacology (ADME, networking, and docking). KEGG analysis and gene ontology demonstrated that chicoric acid works by interfering with many immune system and cancer pathways. Chicoric acid had the best match with receptor proteins 1PXX and 2YCF, which suited the chemical chicoric acid best, with docking scores of - 8.46 and - 9.4, respectively. To sum up, chicoric acid is a new molecule in the medication development process.
More Related Videos
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
07:58Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
Related Concept Videos
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Direct-Acting Cholinergic Agonists: Pharmacokinetics
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
