Related Experiment Video

Updated: May 25, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
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Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

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Hypertension, Obesity, and Target Organ Injury in Children: An Emerging Health Care Crisis

Andrew H Tran1,2, Aaron Walsh3,4, Elaine M Urbina5,6

  • 1The Heart Center, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. andrew.tran@nationwidechildrens.org.

Current Hypertension Reports
|February 27, 2025
PubMed

Insights

Rising childhood hypertension and obesity harm target organs. Early intervention can improve cardiac, renal, and vascular health, reducing long-term cardiovascular risks.

Area of Science:

  • Pediatric Cardiology
  • Public Health
  • Nephrology

Background:

  • Childhood hypertension and obesity prevalence are increasing globally.
  • Health disparities contribute significantly to these rising trends.
  • These conditions activate detrimental pathways like the renin-angiotensin-aldosterone system.

Purpose of the Study:

  • To examine the link between hypertension, childhood obesity, and target organ damage.
  • To review the effects of interventions on these conditions and organ damage.

Main Methods:

  • Systematic review of existing data.
  • Analysis of epidemiological trends.
  • Evaluation of intervention study outcomes.

Main Results:

  • Hypertension and obesity promote inflammation, impacting blood pressure regulation and renal function.
  • Adverse cardiac, vascular, renal, neurocognitive, and retinal changes are associated with elevated blood pressure.
  • Interventions show promise in improving left ventricular hypertrophy, cardiac function, and renal outcomes.

Conclusions:

  • Childhood hypertension and obesity have profound impacts on target organs.
  • Effective management and screening can mitigate future cardiovascular complications.
  • Interventions targeting blood pressure and obesity can reverse or improve organ damage.
Abstract

Keywords:
Carotid intima media thicknessLeft ventricular hypertrophyPediatric hypertensionPediatric obesityPulse wave velocityTarget organ damage

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