Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sleep Apnea

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuroimmunomodulation of AMPA Receptors Through Combination of Medium-Chain Triglycerides and Perampanel to Treat Status Epilepticus in Anti-NMDA Receptor Encephalitis.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology·2026

Same author

Burden among participants with central disorders of hypersomnolence in six European countries.

Sleep medicine·2026

Same author

Aquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders.

Annals of clinical and translational neurology·2026

Same author

Palliative Care in Europe: Safeguarding Compassion Amidst Changing End-of-Life Policies and Expanding Access to Medically Assisted Dying Position Statement on behalf of the European Academy of Neurology, the European Federation of Neurological Associations and OneNeurology.

European journal of neurology·2026

Same author

Climate change and brain health, a risk management approach focusing on the European region: A narrative review.

Journal of the neurological sciences·2026

Same author

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland.

Journal of sleep research·2026

Search research articles

Related Experiment Video

Updated: May 25, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Patients with obstructive sleep apnea in Germany.

Yaroslav Winter^1,2,3, Geert Mayer^4,5, Heike Benes⁶

¹Department of Neurology, University of Saarland, Homburg, Germany. yaroslav.winter@uks.eu.

Sleep & Breathing = Schlaf & Atmung

|February 27, 2025

Summary

Solriamfetol effectively treats excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) patients. Real-world data shows improved EDS symptoms and manageable side effects, with most patients new to this therapy.

Keywords:

Europe Excessive daytime sleepiness Germany Obstructive sleep apnea Real-world evidence Solriamfetol

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

Related Experiment Videos

Last Updated: May 25, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

Area of Science:

Pharmacology and Therapeutics
Sleep Medicine
Real-World Evidence Studies

Background:

Obstructive sleep apnea (OSA) is frequently associated with excessive daytime sleepiness (EDS).
Solriamfetol is an approved medication for treating EDS in OSA patients within the European Union.

Purpose of the Study:

To characterize real-world physician initiation and titration strategies for solriamfetol in OSA patients with EDS.
To evaluate patient experiences and treatment outcomes with solriamfetol in a German real-world setting.

Main Methods:

Retrospective chart review of 83 patients with OSA and EDS in Germany.
Patients were aged 18 years or older, on stable solriamfetol doses for at least 6 weeks.
Initiation strategies analyzed included changeover, add-on, and new-to-therapy.

Main Results:

The majority of patients were new to solriamfetol therapy, typically initiated at 37.5 mg/day.
Solriamfetol treatment led to a significant reduction in Epworth Sleepiness Scale (ESS) scores (mean decrease of 5.4 points).
Approximately 90% of patients reported improvement in EDS symptoms, with most experiencing effects lasting 8 hours and no negative impact on nighttime sleep quality. Headache, decreased appetite, and insomnia were the most common adverse events.

Conclusions:

Solriamfetol initiation at 37.5 mg/day with common titration strategies is effective in a real-world OSA/EDS population.
Significant improvements in EDS symptoms and patient-reported outcomes were observed.
Adverse event profile aligns with previous clinical trial data, suggesting good tolerability.