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Noninvasive Targeted Temperature Management of the Inner Ear: Numerical Simulations and Experimental Measurements in
Maria Fernanda Yepes1, Michael E Hoffer2, Juan Armando Chiossone2
1Department of Neuroscience, University of Miami-Miller School of Medicine.
Summary
Localized, noninvasive mild therapeutic hypothermia (MTH) effectively reduced inner ear temperatures. This approach offers a safe, accessible method for hearing preservation after cochlear injury without systemic side effects.
Area of Science:
- Oto-science
- Biomedical Engineering
- Therapeutic Hypothermia
Background:
- Mild therapeutic hypothermia (MTH) shows protective effects in the cochlea against various injuries.
- Current MTH methods are invasive or systemic, posing risks and limiting clinical use.
- A localized, noninvasive MTH approach is needed for safer hearing preservation.
Purpose of the Study:
- To investigate the efficacy of a localized, noninvasive MTH approach for the human inner ear.
- To assess temperature reductions in the inner ear using a custom cooling gel pack.
- To validate experimental findings with computational modeling.
Main Methods:
- Utilized cadaveric temporal bones with external cooling gel pack application.
- Recorded temperature changes in the inner ear over 30 and 60 minutes.
- Employed finite element analysis on 3D models to simulate heat transfer.
Main Results:
- Inner ear temperatures decreased by up to 4.6°C within 60 minutes.
- Cooling effects persisted for 10 minutes after device removal.
- Numerical models confirmed average temperature reductions of 2°C to 4°C, with sex-based differences noted.
Conclusions:
- Localized, noninvasive MTH successfully lowered inner ear temperatures to therapeutic levels.
- This method presents a promising, clinically translatable strategy for cochlear protection.
- The approach minimizes systemic risks, enhancing safety for hearing preservation.
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