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Impaired decision-making ability in functional heartburn patients
Yue Li1, Jingjing He1, Lulu Zeng1
1Department of Gastroenterology, Second Affiliated Hospital of Anhui Medical University.
Neuropsychology
|February 27, 2025
Summary
Patients with functional heartburn (FH) demonstrate impaired decision-making skills, as evidenced by lower scores on cognitive tasks compared to healthy individuals. This suggests a link between gut-brain disorders and decision-making deficits.
Area of Science:
- Neuroscience
- Gastroenterology
- Psychology
Background:
- Visceral hypersensitivity, common in functional heartburn (FH), is linked to impaired decision-making in animal models.
- Functional heartburn is a gut-brain interaction disorder, but its impact on human decision-making is not well understood.
Purpose of the Study:
- To investigate the decision-making abilities of patients diagnosed with functional heartburn.
- To compare the decision-making performance of FH patients with healthy controls.
Main Methods:
- Thirty patients with FH and 30 healthy controls (HCs) were recruited.
- Cognitive function was assessed using the Iowa Gambling Task (IGT) and Game of Dice Task (GDT).
- Anxiety and depression levels were controlled for in the analysis.
Main Results:
- Patients with FH performed significantly worse on both the IGT and GDT compared to HCs.
- FH patients exhibited lower net scores, made more unfavorable choices, and utilized negative feedback less effectively.
- These deficits persisted even after accounting for anxiety, depression, and functional dyspepsia.
Conclusions:
- Functional heartburn is associated with significantly impaired decision-making abilities.
- These findings highlight the impact of gut-brain interactions on cognitive functions like decision-making.
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