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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

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Structural and Rheological Properties of a Fish Collagen-Based Hydrogel Considered as a Brain Tissue Phantom.

Kaustubh Naik¹, Anastasia S Vanina², Saurabh Kumar Srivastava¹

¹Biophysics and Nanotechnology Laboratory, Department of Physics, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh 221005, India.

Langmuir : the ACS Journal of Surfaces and Colloids

|February 27, 2025

Summary

This study explores fish collagen hydrogels as brain tissue phantoms. These hydrogels show similar rheological properties to brain tissue, offering potential for medical training and research.

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Generation of 3-D Collagen-based Hydrogels to Analyze Axonal Growth and Behavior During Nervous System Development

Generation of 3-D Collagen-based Hydrogels to Analyze Axonal Growth and Behavior During Nervous System Development

Published on: June 25, 2019

Area of Science:

Biomaterials Science
Rheology
Biophysics

Background:

Hydrogels are advanced soft materials that mimic brain tissue properties.
They are utilized in rheological studies, surgical training, and as tissue substitutes.
Fish collagen-based hydrogels offer a promising avenue for biomimetic material development.

Purpose of the Study:

To investigate the shear rheological properties of a novel fish collagen-based hydrogel.
To compare the rheological behavior of the synthesized hydrogel with biological tissue samples.
To assess the potential applications of this hydrogel in various biomedical fields.

Main Methods:

Synthesis of a fish collagen-based hydrogel material.
Characterization of shear rheological properties using amplitude shear sweep tests.
Evaluation of responses to low-frequency oscillatory perturbations.
Comparative analysis with biological tissue samples under identical conditions.

Main Results:

The synthesized fish collagen hydrogel exhibits significant similarity in stress-strain relations to brain tissue.
Storage and loss moduli of the hydrogel closely match those of biological samples.
Both artificial and biological materials show comparable responses to oscillatory perturbations.

Conclusions:

Fish collagen hydrogels demonstrate excellent biomimicry of brain tissue rheological properties.
This material presents a viable option for developing adjustable physical media for research and medical applications.
Further exploration of rheological models and applications is warranted for this promising hydrogel.