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Updated: Jun 14, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
Published on: June 8, 2018
Dynamic regulation of cortical interneuron wiring
Claudia Rosés-Novella1, Clémence Bernard2
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
Abstract:
Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must adapt to changes in cortical activity and environmental information to drive appropriate responses. In this review, we focus on the latest progress in our understanding of the processes that regulate interneuron wiring adaptability. We discuss newly identified types of regulatory processes, from structural synaptic changes to long-range neuromodulation, and provide an update on the activity-dependent molecular underpinnings at the transcriptional and post-transcriptional levels.
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