Visible Light-Mediated Diastereoselective Synthesis of Novel Glycopeptide Mimetics

Herein, we introduce a mild and operationally simple visible-light photochemistry protocol for the synthesis of novel glycopeptide mimetics. This method capitalizes on the reaction between 1,4-dihydropyridine (DHP) containing amino acids and peptides with glycosyl nitrones, showing exceptional stereoselectivity and robust performance across a diverse array of substrates, encompassing both modified glycosides and intricate peptide structures. Furthermore, we underscore the versatility of the resultant compounds through their seamless integration and utility in bioconjugation strategies.