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[Existence of asymptomatic changes in left ventricular function in the diabetic. Noninvasive study]
La Revue De Medecine Interne
|January 1, 1985
Summary
Diabetes significantly impairs left ventricular function, causing prolonged relaxation and reduced contractility, independent of complications. These cardiac changes may stem from metabolic disorders or microangiopathy.
Area of Science:
- Cardiology
- Diabetology
- Biomedical Engineering
Context:
- Diabetes mellitus is a global health concern associated with cardiovascular complications.
- Assessing subclinical cardiac dysfunction in diabetics is crucial for early intervention.
- Noninvasive cardiovascular techniques are vital for evaluating diabetic cardiomyopathy.
Purpose:
- To investigate left ventricular (LV) diastolic and systolic function in diabetic patients without ischemic cardiopathy.
- To determine if observed cardiac abnormalities correlate with diabetes duration, complications, or type.
- To explore potential underlying mechanisms, such as metabolic disorders or myocardial microangiopathy.
Summary:
- Diabetic patients (n=49) exhibited prolonged isovolumetric relaxation time (IVRT) and reduced ejection fraction (EF) slope compared to controls (n=32).
- A high Weissler index (PEP/LVET ratio) indicated impaired myocardial contractility in diabetics, unrelated to preload/afterload.
- Increased septal and posterior wall thickness were observed in diabetics with retinopathy and NIDD, respectively.
Impact:
- Identifies specific left ventricular functional abnormalities in diabetes, distinct from ischemic cardiopathy and hypertension.
- Suggests that metabolic derangements and/or myocardial microangiopathy are potential causes of diabetic cardiomyopathy.
- Highlights the importance of echocardiography in detecting early cardiac dysfunction in diabetic populations.