Related Experiment Video
Updated: Jul 7, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Infection of Immature Mice with Rhinovirus for the Study of Asthma Pathogenesis
Mingyuan Han1, Marc Hershenson2,3
1Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Abstract:
Early-life wheezing-associated respiratory infection with rhinovirus (RV) is a risk factor for asthma development in combination with allergen sensitization and family history. RV infection of immature mice is a useful model to decipher potential immunological mechanisms underlying asthma development following RV infection. Increased type 2 immune response, expansion of group 2 innate lymphoid cells (ILC2s), eosinophilic inflammation, mucous metaplasia, and airway hyperresponsiveness have been observed in RV-infected six-day-old mice. Herein, we present several materials and methods used for propagating and partially purifying RV, measuring RV titers, infecting immature mice with RV, and harvesting lung tissue for whole lung mRNA extraction and flow cytometry.
More Related Videos
09:56Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
Published on: March 2, 2016
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
Related Concept Videos
Respiratory Syncytial Virus Disease
Asthma I: Introduction