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Hs-CRP/ALB Levels Are Associated With Poor Long-term Prognosis in Patients With STEMI Undergoing Percutaneous

Mingyang Li1,2, Yan Zhang3, Xiaodong Cui1,2

  • 1Clinical School of Thoracic, Tianjin Medical University, Tianjin, China.

Angiology
|February 28, 2025
PubMed

Insights

The high-sensitivity C-reactive protein (hs-CRP)/albumin (ALB) ratio is linked to worse outcomes in ST-segment elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). This inflammatory marker predicts major adverse cardiovascular events and mortality, indicating poor long-term prognosis.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Inflammatory biomarkers, including the hs-CRP/ALB ratio, are explored for their prognostic value in cardiovascular diseases.
  • The association between the hs-CRP/ALB ratio and prognosis in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) requires further investigation.

Purpose of the Study:

  • To investigate the independent association between the hs-CRP/ALB ratio and long-term prognosis in STEMI patients treated with PCI.
  • To evaluate the predictive capability of the hs-CRP/ALB ratio for major adverse cardiovascular events (MACE) and all-cause mortality in this patient cohort.

Main Methods:

  • A retrospective cohort study involving 752 STEMI patients undergoing PCI between January 2017 and December 2018.
  • Cox regression analysis was used to assess the association of the hs-CRP/ALB ratio with MACE and all-cause mortality.
  • Receiver operating characteristic (ROC) curve analysis determined the predictive capability of the hs-CRP/ALB ratio for overall mortality.

Main Results:

  • During a median follow-up of 52 months, 24.0% experienced MACE and 10.0% died.
  • The hs-CRP/ALB ratio was independently associated with MACE (continuous HR 1.152, categorical HR 1.257) and all-cause mortality (continuous HR 1.119, categorical HR 2.228).
  • The hs-CRP/ALB ratio demonstrated predictive capability for overall mortality with an AUC of 0.68.

Conclusions:

  • The hs-CRP/ALB ratio is an independent predictor of poor long-term prognosis in STEMI patients undergoing PCI.
  • Elevated hs-CRP/ALB levels are associated with an increased risk of major adverse cardiovascular events and all-cause mortality.
  • The hs-CRP/ALB ratio may serve as a valuable prognostic biomarker in STEMI patients post-PCI.

Keywords:
MACEPCISTEMIall-cause deathhs-CRP/ALBlong-term prognosis

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