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Asymptomatic Carotid Stenosis is Associated With Mobility Dysfunction: Results From the InChianti Study.
Sarasijhaa K Desikan1,2, James Borrelli3,4, Vicki L Gray3
1Division of Vascular Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Vascular and Endovascular Surgery
|February 28, 2025
Summary
Asymptomatic carotid artery stenosis (ACAS) is linked to poorer mobility function in adults aged 65-74. This study highlights a potential connection between carotid health and physical performance in older populations.
Area of Science:
- Gerontology
- Vascular Medicine
- Neurology
Background:
- Older adults with mobility dysfunction face increased risks of falls, hospitalization, and mortality.
- Previous research indicated mobility issues in individuals with asymptomatic carotid artery stenosis (ACAS).
- This study investigates the association between carotid stenosis and mobility in a larger cohort.
Purpose of the Study:
- To evaluate the impact of asymptomatic carotid artery stenosis (ACAS) on mobility function in community-dwelling older adults.
- To analyze mobility performance based on the presence or absence of carotid stenosis.
- To determine if age modifies the relationship between ACAS and mobility.
Main Methods:
- Utilized data from the Invecchiiare in Chianti (InCHIANTI) study, including medical history, carotid duplex testing, and Short Physical Performance Battery (SPPB) scores.
- Excluded participants with a history of stroke, transient ischemic attack, or carotid endarterectomy.
- Employed two-way ANOVA to assess the effects of stenosis, age group (65-74 and 75-84 years), and their interaction on SPPB scores, controlling for sex and cardiovascular risk factors.
Main Results:
- Both carotid stenosis (P = 0.0002) and age group (P < 0.0001) significantly impacted SPPB scores.
- A significant interaction between stenosis and age group was observed (P = 0.0008).
- Participants aged 65-74 with ACAS performed significantly worse on the SPPB (9.81 ± 0.37) compared to those without ACAS (11.10 ± 0.11) (P < 0.0001).
Conclusions:
- Asymptomatic carotid artery stenosis (ACAS) is associated with significantly worse mobility performance in adults aged 65-74.
- The findings suggest a link between carotid artery health and physical function in older adults.
- Further research may explore the mechanisms underlying this association.
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