Related Experiment Video

Updated: May 25, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

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Regulatory Effect of Non-Coding RNAs on Programmed Cell Death in Melanoma: Novel Therapeutic Crosstalk for Targeted

Andarz Fazlollahpour-Naghibi1, Seyed Reza Taha2, Mahdieh Shariatzadeh2

  • 1Faculty of Medicine, Islamic Azad University, Sari Branch, Sari, Iran.

Current Cancer Drug Targets
|February 28, 2025
PubMed

Insights

Non-coding RNAs (ncRNAs) and programmed cell death (PCD) are crucial in melanoma development. Understanding their interplay offers new targeted therapy options for this aggressive skin cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cutaneous melanoma is an aggressive skin cancer with increasing incidence worldwide.
  • Early diagnosis and effective targeted therapies remain critical challenges in melanoma management.
  • Non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs, are implicated in melanoma pathogenesis due to their regulatory roles in cellular processes.

Purpose of the Study:

  • To review the role of programmed cell death (PCD) related non-coding RNAs (ncRNAs) in cutaneous melanoma.
  • To explore the interplay between ncRNAs and PCD as a potential therapeutic strategy for melanoma.
  • To focus on the underlying molecular pathways involved in ncRNA-mediated PCD in melanoma.

Main Methods:

  • Literature review of recent investigations on ncRNAs and PCD in cutaneous melanoma.
  • Analysis of studies focusing on the dysregulation of ncRNAs in melanoma pathogenesis.
  • Examination of research linking PCD pathways to melanoma initiation and progression.

Main Results:

  • Dysregulation of ncRNAs is a significant factor in melanoma development.
  • Programmed cell death (PCD) plays a critical role in the initiation and progression of cutaneous melanoma.
  • The interaction between ncRNAs and PCD pathways presents a promising avenue for novel melanoma therapies.

Conclusions:

  • ncRNAs are key regulators in melanoma, and their dysregulation contributes to the disease.
  • PCD mechanisms are fundamentally involved in melanoma's lifecycle.
  • Targeting the interplay between ncRNAs and PCD offers a novel therapeutic strategy for melanoma treatment.
Keywords:
Melanomaapoptosisautophagyferroptosislong non-coding RNAmicroRNAnon-coding RNApyroptosis.

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