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Updated: May 25, 2025
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
19.2K
Bladder Outcomes in Bilateral Renal Agenesis.
Margaret Meagher1, Elizabeth Ingulli2, Sarah Marietti1
1Department of Urology, Rady Children's Hospital San Diego, San Diego, California, USA.
Pediatric Transplantation
|February 28, 2025
Summary
Children with bilateral renal agenesis (a rare congenital condition) often lack viable bladders. This study details bladder management strategies for these patients undergoing renal transplantation.
Area of Science:
- Pediatric Urology
- Congenital Anomalies
- Renal Medicine
Background:
- Bilateral renal agenesis is a rare congenital urinary anomaly.
- It is associated with lethal pulmonary hypoplasia.
- Amnioinfusion may improve survival but bladder anatomy remains poorly understood.
Purpose of the Study:
- To document bladder anatomy in living patients with bilateral renal agenesis.
- To describe bladder management strategies in these patients undergoing renal transplantation.
Main Methods:
- Retrospective review of five children diagnosed prenatally with bilateral renal agenesis.
- Serial amnioinfusion was administered.
- Clinical course, including transplantation and bladder management, was analyzed.
Main Results:
- None of the five patients had a viable bladder upon radiographic or endoscopic evaluation.
- Four out of five patients received renal transplantation.
- Concurrent cutaneous ureterostomy was performed in transplanted patients.
Conclusions:
- This is the first report detailing bladder anatomy in living patients with bilateral renal agenesis.
- Bladder anomalies necessitate novel urinary drainage management during transplantation.
- A management strategy for urinary drainage in these patients is presented.
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