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Related Experiment Videos

Licensed vaccines.

F T Perkins

    Reviews of Infectious Diseases
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Rubella vaccines utilize live attenuated virus strains grown on various cell substrates. Safe and effective options like RA27/3 and Cendehill are available, with ongoing considerations for combination use and stability testing.

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    Area of Science:

    • Virology
    • Immunology
    • Vaccinology

    Background:

    • Rubella vaccine development has evolved significantly, considering cell substrates, virus strains, and administration routes.
    • Experience with other vaccines informed the safety and efficacy assessments of rubella vaccines.

    Purpose of the Study:

    • To review the current landscape of rubella vaccines, including their production, safety, and efficacy.
    • To discuss the considerations for rubella vaccine usage, both alone and in combination with other vaccines.
    • To highlight areas for potential revision in international vaccine requirements.

    Main Methods:

    • Review of established cell substrates for rubella vaccine production, including animal and human diploid cells.
    • Analysis of licensed rubella vaccine strains and their historical performance.

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  • Evaluation of administration routes and safety profiles based on available data.

    • Main Results:

    • Several cell substrates, including duck, rabbit, quail, and human diploid cells, are suitable for rubella vaccine production.
    • Live attenuated rubella virus strains are the basis for current vaccines.
    • RA27/3 and Cendehill are identified as safe and effective, widely available rubella vaccines.

    Conclusions:

    • The choice of rubella vaccine and its combination with other vaccines is a key national decision.
    • World Health Organization requirements for rubella vaccines, established in 1976, require updates.
    • The inclusion of a stability test in vaccine requirements is crucial, particularly for developing countries.