The inhibition of norepinephrine release in nasal mucosa by acetylcholine

Tritiated norepinephrine was incorporated into isolated dog nasal mucosa. Electrical stimulation of this mucosa induced a release of the tritiated norepinephrine. Acetylcholine inhibited this release in a dose-related manner. The inhibition is prevented by atropine. This data provides further evidence for the existence of presynaptic, inhibitory, muscarinic receptors on the sympathetic nerve terminals in nasal blood vessels.