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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

61
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
61
Acute Pharyngitis01:30

Acute Pharyngitis

354
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
354
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

207
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
207
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

79
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
79
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

147
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
147

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A Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology Clinical Practice Statement: Management of social eating and drinking challenges in adults with cancer.

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Aphthous-Like Stomatitis in a Patient Receiving Panitumumab.

Maria Kouri1, Erofili Papadopoulou1, Styliani Tziveleka1

  • 1Department of Oral Medicine & Oral Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, AthensGreece.

Journal of Oral & Maxillofacial Research
|February 28, 2025
PubMed
Summary

Panitumumab, an anti-epithelial growth factor receptor antibody, can cause rare oral side effects like aphthous-like stomatitis. Prompt treatment with dexamethasone and tramadol effectively managed symptoms, allowing continued cancer therapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Oral Medicine

Background:

  • Panitumumab is an anti-epithelial growth factor receptor (EGFR) monoclonal antibody used for metastatic colorectal cancer.
Keywords:
aphthous-like ulcerscolorectal cancerpanitumumabstomatitis

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  • While skin toxicity is common, oral adverse events associated with panitumumab are rarely reported.
  • This case report details panitumumab-induced aphthous-like stomatitis.