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Related Experiment Video

Updated: May 25, 2025

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
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Assessing cognitive flexibility in mice using a custom-built touchscreen chamber.

Rui C Pais1, Ali Goldani1, Jayden Hutchison1

  • 1Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.

Frontiers in Behavioral Neuroscience
|February 28, 2025
PubMed
Summary
This summary is machine-generated.

We developed a low-cost automated touchscreen system for rodent cognitive and behavioral screening. This system identified potential genotype-specific deficits in an Alzheimer's Disease (AD) mouse model, validating its utility for neurobiological research.

Keywords:
Alzheimer’s diseaseRaspberry Picognitive flexibilityserial reversal learningtouchscreen chamber

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Biotechnology

Background:

  • Automated touchscreen systems are crucial for rodent model screening in cognitive and behavioral research.
  • High costs of existing systems create barriers to accessibility in basic research.
  • Bridging the translational gap between animal models and human clinical research is essential.

Purpose of the Study:

  • To introduce a cost-effective, custom-built touchscreen operant conditioning chamber using Raspberry Pi and a tablet.
  • To validate the apparatus by assessing cognitive and behavioral performance in mice.
  • To investigate potential genotype-specific deficits in an Alzheimer's Disease (AD) mouse model.

Main Methods:

  • Developed a novel touchscreen operant chamber using Raspberry Pi and a commercial tablet.
  • Trained C57BL/6 mice on a visual discrimination serial-reversal task.
  • Trained C57BL/6 and AppNL-G-F (AD model) mice on a location discrimination serial-reversal task.

Main Results:

  • Mice demonstrated clear progression toward asymptotic performance on the location discrimination task.
  • AppNL-G-F mice showed increased errors during reversal learning compared to wild-type controls.
  • Potential genotype-specific deficits were observed in the AD mouse model.

Conclusions:

  • The custom-built touchscreen apparatus is a practical and cost-effective tool for rodent behavioral research.
  • The system can provide valuable insights into cognitive and behavioral markers of neurobiological disorders like Alzheimer's Disease.
  • This technology enhances the utility of rodent models for translational research.