Related Experiment Video
Updated: May 25, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Characterising patterns in routinely reported longitudinal HIV data in South Africa using a Bayesian multiplicative
Bareng A S Nonyane1, Laura Steiner2, Kate Shearer2
1Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Discrepancies between HIV treatment databases were analyzed using a Bayesian model. The study found minor differences in ART initiation data, with a few facilities showing significant data gaps.
Area of Science:
- Health Informatics
- Epidemiology
- Biostatistics
Background:
- Longitudinal aggregated healthcare data from multiple facilities require robust analytical methods.
- Identifying discrepancies between routinely collected health data sources is crucial for data quality.
Purpose of the Study:
- To characterize patterns and identify discrepancies in longitudinal aggregated healthcare data between two database systems.
- To quantify the time effect and facility-specific variations in antiretroviral treatment (ART) initiations.
Main Methods:
- Utilized routinely collected data on ART initiations in 69 South African facilities in 2019 from Tier.net and DHIS.
- Employed a Bayesian multiplicative interaction model to analyze heterogeneous facility-specific slopes and database discrepancies.
Main Results:
- Average trends showed seasonal dips in ART initiations, particularly in December.
- Facility-specific slopes revealed distinct fluctuation patterns over time.
- Median difference in monthly ART initiations between databases was 1.6, with 3 facilities showing discrepancies of over 10 initiations.
Conclusions:
- Bayesian multiplicative interaction models effectively quantify trends and discrepancies in multi-facility healthcare data.
- The Bayesian framework efficiently estimates parameters for numerous facilities with heterogeneous time slopes.
Related Concept Videos
Statistical Methods for Analyzing Epidemiological Data
Longitudinal Studies
Mechanistic Models: Compartment Models in Individual and Population Analysis
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Longitudinal Research
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...

