Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Early-life famine exposure, particularly during fetal development and childhood, increases the risk of developing metabolic dysfunction-associated fatty liver disease (MAFLD) later in life. This highlights the importance of adequate early nutrition for preventing MAFLD.
Area Of Science
- Public Health
- Epidemiology
- Nutritional Science
Background
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent global health issue, affecting approximately one-third of the world's population.
- The impact of early-life famine exposure on MAFLD development in diverse populations, such as those in less-developed southwest China, requires further investigation.
Purpose Of The Study
- To investigate the association between early-life famine exposure and the risk of developing MAFLD in adulthood.
- To examine potential differences in this association across various developmental stages (fetal, childhood, adolescence) and ethnic groups.
Main Methods
- A cohort of 18,558 participants from the China Multi-Ethnic Cohort Study in Yunnan was analyzed.
- Participants were categorized based on birth year to represent different famine exposure periods: fetal, childhood, adolescence, and non-exposed.
- Logistic regression models were employed to assess the relationship between famine exposure timing and MAFLD risk.
Main Results
- Early-life famine exposure significantly elevates the risk of MAFLD in adulthood.
- Famine exposure during fetal life and childhood showed a pronounced association with increased MAFLD risk, especially in the Bai population.
- Fetal famine exposure in males was linked to a higher risk of developing MAFLD in adulthood.
Conclusions
- Adequate nutrition during early life, including fetal development, is crucial for preventing MAFLD in adulthood.
- A comprehensive, lifelong strategy is recommended for chronic liver disease prevention, emphasizing interventions from the fetal stage onwards.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...