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Updated: May 25, 2025
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Transarterial Embolization for the Management of Brain Arteriovenous Malformations: A Systematic Review
Kenichi Sato1, Yasushi Matsumoto2, Masayuki Ezura1
1Department of Neurosurgery, Sendai Medical Center, Sendai, Miyagi, Japan.
Objective:
The authors aimed for a systematic review to clarify the current role of transarterial embolization (TAE) in the management of brain arteriovenous malformations (BAVMs).
Methods:
A search was conducted on PubMed, using the following terms; "brain arteriovenous malformation," "cerebral arteriovenous malformation," "endovascular treatment," and "transarterial embolization." Studies reporting the efficacy and safety of endovascular treatment for BAVMs, performed either as a standalone treatment or in conjunction with surgery or radiosurgery, were included. The final search was conducted in December 2023. Only articles written in English were reviewed. The references of publications of interest were also screened. Studies on transvenous embolization were excluded. More than 100 articles on the treatment of BAVMs were reviewed.
Results:
Advances in endovascular techniques and devices have enabled TAE as a treatment modality for BAVMs, to achieve higher embolization rates. Thus, curative TAE for some BAVMs with suitable angioarchitecture has become possible. The efficacy of presurgical TAE in the treatment of low Spetzler-Martin grade BAVMs is limited; however, TAE is effective for intermediate grade BAVMs. Several reports using propensity-matched analyses reevaluated the therapeutic efficacy of pre-/post-radiosurgical TAE for BAVMs with radiosurgery-resistant lesions such as large nidus, fistulous components, and associated aneurysms. The complication rate of TAEs as a treatment modality for BAVMs is approximately 10%, and hemorrhagic complications occur in approximately 5% of cases. Despite recent advances, substantial improvements have not been observed in the morbidity and mortality associated with TAEs for the treatment of BAVMs.
Conclusion:
TAE for the treatment of BAVMs is primarily performed in an adjuvant manner; however, recent advances have made standalone embolization possible. A multidisciplinary team should evaluate each case independently. Furthermore, as per recent studies, inclusive of meta-analyses, the efficacy and safety of TAEs for the treatment of BAVMs have not been elucidated. Thus, the manifestations and characteristics of BAVMs, in addition to the objective of performing a TAE, should be deliberated carefully before the endovascular procedure, to avoid complications.
