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Cell movement and contraction in somite development.

Scanning Electron Microscopy

|January 1, 1985

Summary

This summary is machine-generated.

Somite segmentation involves cell shape changes and contractions. Sclerotome dispersal, crucial for vertebral column development, requires cell movement and extracellular matrix production.

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Area of Science:

Developmental Biology
Cell Biology
Biochemistry

Background:

Somite formation is a key developmental process where segmental plate mesoderm forms epithelial structures.
Sclerotome dispersal is essential for the development of the vertebral column.

Purpose of the Study:

To investigate the cellular mechanisms underlying somite segmentation and sclerotome dispersal.
To explore the role of cell contraction, microfilaments, microtubules, and extracellular matrix in these processes.

Main Methods:

Experimental manipulation using drugs affecting microfilaments, microtubules, and calcium-dependent contraction.
Observation of cellular changes in shape, position, adhesion, and extracellular matrix accumulation.

Main Results:

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Calcium-dependent contraction, potentially calmodulin-mediated, is involved in cell elongation and apical contraction during segmentation.
Active cell movement and extracellular matrix production are critical for sclerotome dispersal.

Conclusions:

Somite segmentation and sclerotome dispersal are complex morphogenetic events regulated by cytoskeletal dynamics and cell adhesion.
The findings reveal similarities between somite development and contractile morphogenetic events in other epithelial organ systems.