Related Experiment Video

Updated: May 24, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

8.7K

Systemic treatment patterns and adherence to guidelines in Japanese patients with metastatic non-small cell lung

Keiko Nishimyo1, Shunya Ikeda1, Kiyohide Fushimi2

  • 1Department of Social Medical Sciences, Graduate School of Medicine, International University of Health and Welfare, Minato-ku, Tokyo, Japan.

Future Oncology (London, England)
|February 28, 2025
PubMed
Abstract

Insights

Japanese non-small-cell lung cancer (NSCLC) treatment patterns varied by age and histology. Guideline adherence was highest in younger patients with squamous NSCLC, indicating a need for better drug application and dissemination.

Area of Science:

  • Oncology
  • Pharmacology
  • Public Health

Background:

  • Treatment patterns and guideline adherence for non-small-cell lung cancer (NSCLC) in Japan are not well-defined.
  • Understanding these factors is crucial for optimizing patient care and outcomes.

Purpose of the Study:

  • To investigate and analyze NSCLC treatment patterns and guideline adherence among Japanese patients.
  • To identify factors influencing adherence, including age and tumor histology.

Main Methods:

  • Retrospective analysis of diagnostic procedure combination data for 9,722 patients with stage IV NSCLC treated between 2016-2018.
  • Logistic regression was used to evaluate factors impacting guideline adherence.

Main Results:

  • Treatment strategies differed significantly between younger (<75) and older (≥75) patients, and by histology (squamous vs. nonsquamous).
  • Platinum combination therapy was common in first-line treatment for both age groups and histologies.
  • Immune checkpoint inhibitors and cytotoxic chemotherapy were frequently used in second- and third-line settings, particularly in nonsquamous NSCLC.
  • Guideline adherence was highest (90%) in patients under 75 with squamous NSCLC.
  • Age, histology, activities of daily living, and hospitalization history influenced adherence.

Conclusions:

  • Introduction of new NSCLC drugs has increased across age groups, suggesting improved prognoses.
  • There is a need for more efficient drug utilization and wider dissemination of treatment guidelines to enhance NSCLC patient care in Japan.
Keywords:
JapanNon-small cell lung cancerreal-world datatreatment adherencetreatment efficacytreatment pattern

More Related Videos

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.2K
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.0K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
163
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
126
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
34