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Oxidative Stress in Pediatric Asthma: Sources, Mechanisms, and Therapeutic Potential of Antioxidants

Yanhua Han1, Mingyao Zhang2, Shishu Yu2

  • 1Department of Pediatrics, Affiliated Hospital to Changchun University of Chinese Medicine, 130021 Changchun, Jilin, China.

Frontiers in Bioscience (Landmark Edition)
|February 28, 2025
PubMed

Insights

Pediatric asthma involves oxidative stress from inflammation and environmental factors. Understanding these sources is key to developing new antioxidant therapies for children with asthma.

Area of Science:

  • Pediatric Pulmonology
  • Environmental Health
  • Biochemistry

Background:

  • Pediatric asthma is a prevalent respiratory illness in children.
  • Oxidative stress in asthmatic airways is linked to disease progression, but mechanisms are unclear.
  • Reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to airway inflammation.

Purpose of the Study:

  • To review the origins of oxidative stress in pediatric asthma.
  • To elucidate the role of oxidative stress in asthma development.
  • To explore antioxidant therapies for pediatric asthma.

Main Methods:

  • Literature review on oxidative stress in pediatric asthma.
  • Analysis of environmental and genetic factors contributing to ROS/RNS production.
  • Examination of cellular signaling pathways affected by oxidative stress.

Main Results:

  • Inflammatory cells and external pollutants are primary sources of ROS/RNS in pediatric asthma.
  • Accumulated reactive species disrupt redox balance, activating inflammatory pathways.
  • Oxidative stress exacerbates asthma inflammation and progression.

Conclusions:

  • Understanding oxidative stress is vital for treating pediatric asthma.
  • Antioxidant-based strategies show promise for therapeutic intervention.
  • Further research into antioxidant mechanisms is warranted for pediatric asthma management.

Keywords:
antioxidantinflammatoryoxidative stresspediatric asthma

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