Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.0K
Teeth01:15

Teeth

282
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
282
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A historical perspective on the discovery of human dental follicle cells for regenerative dentistry.

Archives of oral biology·2026
Same author

Inhibition of protein kinase C activity enables mineralization of senescent dental follicle cells with almost no osteogenic differentiation potential.

Archives of oral biology·2025
Same author

Reduced free cholesterol in dental follicle cells inhibits osteogenic differentiation by inducing protein kinase C activity.

Biochemical and biophysical research communications·2025
Same author

The Role of Protein Kinase C During the Differentiation of Stem and Precursor Cells into Tissue Cells.

Biomedicines·2025
Same author

Sclerostin inhibits Protein kinase C inhibitor GÖ6976 induced osteogenic differentiation of dental follicle cells.

Tissue & cell·2024
Same author

Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation.

Biomedicines·2023
Same journal

AKT-mTOR/P53 PathwayDriven RapamycinAlpelisib Efficacy in Animal Models of TIE2Mutant Venous Malformations.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Dual Role of Nitric Oxide in Tumor Immunity and Its Therapeutic Application.

Frontiers in bioscience (Landmark edition)·2026
Same journal

The Metabolic States of Cancer-Associated Fibroblasts: Targeting Stromal Reprogramming to Impede Tumor Progression and Immune Evasion.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Functional Changes in Mitochondrial Subpopulations of Left Ventricular Cardiomyocytes in Post-Infarction Rats During the Subacute Stage of Remodeling.

Frontiers in bioscience (Landmark edition)·2026
Same journal

TRPM7 Channel-Mediated Mitochondrial Oxidative Stress Induces Dysfunction of Müller Cells Under High Glucose and Low Mg<sup>2+</sup> Stress.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Navigating the Redox Precipice: Metabolic Gatekeeping as a Therapeutic Window in Pancreatic Precancer.

Frontiers in bioscience (Landmark edition)·2026
See all related articles

Related Experiment Video

Updated: May 24, 2025

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
07:56

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

6.7K

Current Topics in Dental Follicle Cell Research.

Christian Morsczeck1

  • 1Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

Frontiers in Bioscience (Landmark Edition)
|February 28, 2025
PubMed
Summary
This summary is machine-generated.

Dental follicle cells (DFCs) are promising dental stem cells for regenerative dentistry. Recent research highlights their role in periodontal development and regeneration, but clinical application requires further preclinical study.

Keywords:
immune therapyosteogenic differentiationperiodontal regenerationtissue engineeringtooth development

More Related Videos

Isolation of Epithelial Cells from Human Dental Follicle
04:07

Isolation of Epithelial Cells from Human Dental Follicle

Published on: November 5, 2021

2.8K
Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

26.3K

Related Experiment Videos

Last Updated: May 24, 2025

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
07:56

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

6.7K
Isolation of Epithelial Cells from Human Dental Follicle
04:07

Isolation of Epithelial Cells from Human Dental Follicle

Published on: November 5, 2021

2.8K
Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

26.3K

Area of Science:

  • Dental stem cells research
  • Regenerative dentistry
  • Periodontal development

Background:

  • Dental follicle cells (DFCs) are a type of dental stem cell sourced from tooth germs or unerupted wisdom teeth.
  • DFCs play a crucial role in the development of the periodontium and the process of tooth eruption.
  • Research interest in DFCs has grown significantly since their initial isolation.

Purpose of the Study:

  • To summarize key research on Dental Follicle Cells (DFCs) from the past five years.
  • To provide an overview of current basic and preclinical research topics involving DFCs.
  • To assess the progress and future potential of DFCs in regenerative dentistry.

Main Methods:

  • Review of significant scientific articles published within the last five years.
  • Focus on basic research concerning tooth development, eruption, and osteogenic differentiation.
  • Analysis of preclinical research in regenerative therapies and immunotherapies using DFCs.

Main Results:

  • DFCs have enhanced the understanding of periodontal development and regeneration mechanisms.
  • Basic research has elucidated molecular pathways in osteogenic differentiation.
  • Preclinical studies demonstrate potential for DFCs in regenerative and immunotherapies.

Conclusions:

  • DFC research is vital for advancing future regenerative dentistry.
  • Significant progress has been made in understanding DFC capabilities.
  • Further preclinical validation is necessary before routine clinical integration of DFCs is possible.