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Related Experiment Video

Updated: May 24, 2025

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Molecular Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients.

Piero Giuseppe Meliante¹, Sofia Pizzolante¹, Luca Perna²

¹Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), "Sapienza" University of Rome, Sant'Andrea Hospital, 00189 Rome, Italy.

Frontiers in Bioscience (Landmark Edition)

|February 28, 2025

Summary

Accurate diagnosis of lymph node metastasis in head and neck cancer is challenging. This review identifies molecular markers like miR-205 and E-cadherin to improve detection and treatment for head and neck squamous cell carcinoma (HNSCC).

Keywords:

cancer marker head and neck squamous cell carcinoma lymp node meastasis occult metastasis regional metastasis

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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Area of Science:

Oncology
Molecular Biology
Pathology

Background:

Accurate diagnosis of regional lymph node metastasis is crucial for head and neck cancer (HNSCC) treatment planning.
Current radiological techniques face challenges in detecting nodal metastasis, potentially leading to undertreatment or overtreatment.
Identifying reliable molecular markers is essential to improve diagnostic accuracy in HNSCC.

Purpose of the Study:

To review and identify molecular markers associated with occult metastasis in head and neck squamous cell carcinoma (HNSCC).
To analyze markers based on their location: lymph node, tumor tissue, and blood.
To highlight promising markers for improved diagnostic precision in HNSCC.

Main Methods:

Comprehensive literature review of studies analyzing molecular markers in HNSCC.
Categorization of identified markers by analysis type: lymph node, tumor tissue, and blood.
Evaluation of marker effectiveness across various studies and subsites.

Main Results:

Numerous molecular markers were identified across lymph node, tumor tissue, and blood analyses.
Promising markers demonstrating effectiveness include miR-205, desmoglein 3 (DSG3), pan-cytokeratin (CK) AE1/AE3, HPV-16, activin-A, cyclin D1, E-cadherin, and neural progenitor lineage (NPL).
These markers show potential for enhancing the detection of occult metastasis in HNSCC.

Conclusions:

Several molecular markers show promise for improving the diagnosis of lymph node metastasis in HNSCC.
Combination scoring systems using these markers could enhance diagnostic precision.
Further research focusing on integrated marker approaches is recommended to optimize treatment selection for HNSCC patients.