A retrospective study of risk factors for thrombosis in patients with ITP

ITP is not only a bleeding disease but also a potential thrombotic disease.

This retrospective study analyzed the factors associated with the occurrence of thrombosis events in ITP patients.

The overall incidence of thrombosis was 4.66% (15/322), with the incidence of arterial events was 2.17% (7/322) and of venous thrombosis was 2.80% (9/322). Thrombosis can occur in all stages and was more common in patients with chronic ITP (66.7%). In univariate logistic analysis, age (OR = 1.037, 95%CI (1.003,1.072), p = 0.032), hypertension (OR = 3.389, 95%CI (1.184,9.699), p = 0.023), coronary artery disease (OR = 10.714, 95%CI (2.462,46.619), p = 0.002), dyslipidemia (OR = 4.325, 95%CI (1.463,12.788), p = 0.008), and treatment with TPO-RAs (OR = 5.233, 95%CI (1.448,18.918), p = 0.012) were related to increased risk thrombotic events. In multivariate logistic analysis, results showed that coronary artery disease (OR = 9.486, 95% CI (1.858, 48.42), p = 0.007), dyslipidemia (OR = 3.983, 95% CI (1.255, 12.641), p = 0.019), as well as TPO-RAs treatment (OR = 4.591, 95% CI (1.238, 17.023), p = 0.023), were independent risk factors for thrombosis in ITP patients (p < 0.05).

Thrombotic events can occur at all stages of ITP with a higher percentage in chronic ITP. Coronary artery disease, dyslipidemia and TPO-RAs treatment are independent risk factors related to thrombosis in ITP patients.