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Updated: May 24, 2025

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
Synthesis and stability of collagen mimetic peptides featuring δ-heteroatom-substituted prolines
Taylor A Gerrein1, Madison M Wright1, Natalia Cano-Sampaio1
1Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA. jdelval2@nd.edu.
Abstract:
We describe the first investigation of collagen mimetic peptides harboring proline surrogates with heteroatoms at the δ-position. While dehydro-δ-azaproline and (N-methyl)-δ-azaproline destabilized the parent structure, replacement of the Xaa proline residue with δ-oxaproline resulted in a faster-folding collagen mimetic peptide with equivalent thermal stability.
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