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Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Doppler Optical Coherence Tomography of Retinal Circulation

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Published on: September 18, 2012

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time

Hiroyuki Takahashi^1,2,3, Yunchan Hwang², Jungeun Won²

¹New England Eye Center, Tufts Medical Center, Boston, MA, USA.

Translational Vision Science & Technology

|February 28, 2025

Summary

This study introduces a new method to measure blood flow speed in retinal microaneurysms in diabetic retinopathy. Slower blood flow in microaneurysms is linked to fluid leakage, aiding diabetic macular edema research.

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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

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Published on: February 18, 2022

Area of Science:

Ophthalmology
Medical Imaging
Fluid Dynamics

Background:

Diabetic retinopathy (DR) is a leading cause of vision loss.
Microaneurysms (MAs) are early signs of DR, but their blood flow dynamics are not well understood.
Understanding MA blood flow may offer insights into diabetic macular edema (DME) development.

Purpose of the Study:

To quantify blood flow speed within retinal microaneurysms (MAs) in eyes with diabetic retinopathy (DR).
To investigate the relationship between MA blood flow speed and clinical characteristics, such as intraretinal fluid (IRF).

Main Methods:

Utilized Variable Interscan Time Analysis (VISTA) with high-speed swept-source optical coherence tomography angiography (OCTA).
Quantified VISTA flow speed (VFS) in 123 MAs across 24 eyes with DR.
Correlated VFS with MA intraluminal reflectivity, axial location, and presence of surrounding IRF.

Main Results:

Mean VFS in MAs was 1.26 ms⁻¹.
MAs with higher intraluminal reflectivity exhibited slower VFS.
MAs located near IRF showed significantly slower VFS (1.16 ms⁻¹) compared to those without IRF (1.37 ms⁻¹).

Conclusions:

VISTA OCTA is a viable method for assessing MA blood flow speed in DR.
Decreased blood flow speed in MAs is associated with the presence of IRF, suggesting a link to DME pathogenesis.