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Risk factors of high inflammatory state in pediatric obstructive sleep apnea

Yanyu He1, Xueyun Xu1, Meng Lv1

  • 1Department of Respiratory, Children's Hospital Affiliated to Soochow University, No. 303, Jingde Road, Suzhou, Jiangsu Province, China.

Sleep & Breathing = Schlaf & Atmung
|February 28, 2025
PubMed

Insights

High inflammatory status in pediatric obstructive sleep apnea (OSA) is linked to higher BMI and apnea duration. High-sensitivity C-reactive protein (hsCRP) can identify children with this high inflammatory status.

Area of Science:

  • Pediatric Sleep Medicine
  • Cardiovascular Health
  • Inflammation Research

Background:

  • Obstructive sleep apnea (OSA) may cause chronic systemic inflammation, contributing to complications.
  • Identifying high inflammatory status (HIS) in pediatric OSA is vital for diagnosis and management.
  • This study evaluated factors influencing hsCRP and risks for HIS in pediatric OSA.

Purpose of the Study:

  • To assess factors influencing high-sensitivity C-reactive protein (hsCRP) levels.
  • To identify risk factors associated with high inflammatory status (HIS) in pediatric OSA patients.

Main Methods:

  • Included 1,171 children (3-15 years) with snoring symptoms undergoing polysomnography (PSG).
  • Collected data via questionnaires, physical exams (BMI, tonsillar hypertrophy), nasopharyngeal X-ray, and blood tests.
  • Used ROC curves to establish hsCRP thresholds for HIS and Low Inflammatory Status.

Main Results:

  • 562 children diagnosed with OSA; 299 had HIS, 872 had Low Inflammatory Status.
  • Pediatric OSA patients with HIS showed significantly higher hsCRP levels, BMI, and rates of overweight/obesity.
  • Logistic regression revealed HIS correlated positively with BMI and mean obstructive apnea time, and negatively with minimum SpO2.

Conclusions:

  • HsCRP levels are elevated in pediatric OSA patients with HIS.
  • BMI, mean obstructive apnea time, and minimum SpO2 are independent factors contributing to HIS.
  • hsCRP serves as an effective blood biomarker for identifying HIS in pediatric OSA.
Abstract

Keywords:
Hypersensitivity C-reactive proteinPediatric obstructive sleep apneaPolysomnographyRisk factorsSystemic inflammation

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