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Metabolic Alterations in HSCs during Aging and Leukemogenesis
Yi-Hsuan Chiang1, Stephan Emmrich1, Nicola Vannini1
1Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
Physiology (Bethesda, Md.)
|February 28, 2025
Summary
Aging alters cellular metabolism, impacting hematopoietic stem cells. This review explores metabolic changes in aged stem cells and strategies to reverse these aging-related effects.
Area of Science:
- Gerontology
- Hematology
- Metabolic pathways
Background:
- Aging leads to a decline in cellular function across all lifeforms.
- Metabolism is profoundly altered during the aging process.
- Hematopoietic stem cell (HSC) function is intrinsically linked to their energy metabolism.
Purpose of the Study:
- To review recent advancements in understanding aged HSC metabolism.
- To explore molecular regulators of HSC metabolic changes.
- To discuss the impact of metabolic perturbations on hematopoiesis and leukemogenesis.
Main Methods:
- Literature review of current research on aging and hematopoiesis.
- Analysis of molecular players and pathways in HSC metabolism.
- Examination of consequences of altered metabolism on clonal hematopoiesis and leukemogenesis.
Main Results:
- Aged HSCs exhibit distinct metabolic states and changes.
- Specific molecular players and pathways are involved in aged HSC metabolism.
- Perturbed metabolism contributes to clonal hematopoiesis and leukemogenesis.
Conclusions:
- Metabolic alterations in HSCs are a key feature of aging.
- Understanding these metabolic changes is crucial for addressing age-related blood disorders.
- Pharmacologic and genetic interventions show promise for rejuvenating aged HSC metabolism.
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