New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning
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Marnix H Medema1,2, Gilles P van Wezel2
1Bioinformatics Group, Wageningen University, Wageningen, The Netherlands.
Plos Biology
|February 28, 2025
Abstract:
With the explosive increase in genome sequence data, perhaps the major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. We discuss the challenges and state-of-the-art of antibiotic discovery based on ecological principles, genome mining and artificial intelligence.
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