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Extrinsic chiral plasmonic sensors based on a nanohole array.

Siyi Wang, Zhijun Zhao, Shanshan Huang

|February 28, 2025

Summary

This summary is machine-generated.

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This study introduces a novel chiral plasmonic sensor (CPS) using a nanohole array. This extrinsic CPS distinguishes between enantiomers with high sensitivity and precision, offering a new approach for molecular structure determination.

Area of Science:

Plasmonics and Nanophotonics
Chiroptical Sensing
Biomolecular Structure Determination

Background:

Enantiomer stereochemistry is crucial for biomedicine, bioscience, and food safety due to distinct biological functions.
Chiral plasmonic sensors (CPSs) offer ultra-sensitive detection via superchiral electromagnetic fields but typically require multiple samples, reducing precision and increasing cost.

Purpose of the Study:

To develop and demonstrate an extrinsic chiral plasmonic sensor (CPS) based on a nanohole array (NHA) for precise enantiomer structure determination.
To overcome the limitations of traditional CPSs that rely on intrinsic chiroptical effects and multiple sample measurements.

Main Methods:

Theoretical and experimental demonstration of an extrinsic CPS utilizing a nanohole array (NHA).
Coating the NHA with a chiral medium to induce distinct responses for different enantiomers.

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Analyzing the changes in negative and positive g-factors for L- and D-phenylalanine.

Main Results:

The NHA-based extrinsic CPS showed simultaneous increases in negative and positive g-factors for L-phenylalanine and decreases for D-phenylalanine.
These distinct signal patterns provide clear criteria for determining molecular structures.
Achieved a detection sensitivity enhancement of approximately 1 × 10⁶ times compared to traditional methods.

Conclusions:

The developed extrinsic CPS based on NHA offers a novel, high-performance approach for enantiomer structure determination.
The enhanced sensitivity is attributed to the superchiral field near nanoholes and its dependence on the real and imaginary parts of the Pasteur constant.
This method provides a precise and cost-effective alternative for analyzing chiral biomolecules.