Global systematic mapping of Vibrio species pathogenicity: A PRISMA-guided cluster-based analysis
Hope Onohuean1,2,3, Uchechukwu U Nwodo3
1Biopharmaceutics Unit, Department of Pharmacology and Toxicology, School of Pharmacy, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda.
Medicine
|February 28, 2025
Summary
This study maps global Vibrio research on toxigenesis and virulence factors. Findings highlight the complexity of Vibrio virulence, emphasizing an interdisciplinary approach for future interventions.
Area of Science:
- Microbiology
- Genomics
- Public Health
Background:
- Vibrio species pose significant public health threats due to their toxigenesis and virulence factors.
- Understanding global research patterns is crucial for developing effective interventions against Vibrio infections.
Purpose of the Study:
- To systematically map and analyze global research on Vibrio toxigenesis and genomic virulence.
- To identify emerging research patterns and establish a database for future intervention strategies.
Main Methods:
- A systematic literature analysis was conducted using Web of Science and Scopus databases.
- Voxviewer software was employed to map global publications on Vibrio spp. or virulence toxin/genes.
- Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) strategies were used for standardization.
Main Results:
- A total of 1162 publications were identified, with 314 studies meeting the inclusion criteria for detailed analysis of virulence factors.
- Co-citation analysis revealed 4 thematic clusters, with "pathogenesis & virulence factors" and "host response factors" showing the most and least research interest, respectively.
- Bibliographic coupling identified 8 thematic clusters, with "cluster#1" and "cluster#8" attracting the most and least research attention.
Conclusions:
- Vibrio toxigenesis and virulence factors represent a complex research area.
- An interdisciplinary approach integrating diverse perspectives is essential for advancing the field.
- These findings have significant implications for both academic research and public health policy.
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