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The overgrowth of structure-function coupling in premature brain during infancy
Rong Wang1, Tianyu Fang1, Yue Zhang1
1Medical School，Faculty of Medicine, Tianjin University, Tianjin, China; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin University, Tianjin, China; Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, China; Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin, China.
Developmental Cognitive Neuroscience
|February 28, 2025
Summary
Preterm infants show altered brain development, with faster structure-function coupling growth than full-term infants. This study reveals differences in early brain development and information processing in preterm infants.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Imaging
Background:
- Infant brain development involves rapid growth in structure and function.
- The coupling between brain structure and function in infants is not well understood.
- Understanding this coupling is crucial for identifying developmental trajectories.
Purpose of the Study:
- To investigate the coupling between brain structure and function in infants.
- To examine how prematurity affects this structure-function coupling.
- To quantify developmental patterns in preterm infants' brains.
Main Methods:
- Utilized multimodal magnetic resonance imaging (MRI) data from the developing Human Connectome Project (dHCP) database.
- Analyzed coupling patterns across different brain regions, including unimodal and transmodal cortices.
- Compared structure-function coupling in preterm and full-term infants at term-equivalent age.
Main Results:
- A similar pattern of coupling distribution was observed in both preterm and full-term infants.
- Coupling varied across specific brain regions like visual, sensorimotor, and default mode network.
- Preterm infants exhibited widespread overgrowth of structure-function coupling.
- Preterm infants showed a slower developmental trajectory compared to full-term infants.
Conclusions:
- The study successfully quantified structure-function relationships in the developing brains of preterm infants.
- Findings offer new insights into information transmission processes in the early-life brain.
- Highlights the impact of prematurity on brain development and functional connectivity.
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