Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age estimation through CT image analysis of the thoracic cage in a Mediterranean population.

International journal of legal medicine·2025
Same author

Sex estimation by CT image analysis of the rib cage in a Mediterranean population.

International journal of legal medicine·2024
Same author

Validation of age estimation methods through the scapula in a Mediterranean non-adult population.

International journal of legal medicine·2024
Same author

Age estimation in infant and prenatal individuals through the metric development of the pars petrosa and squamosal portion of the temporal bone.

International journal of legal medicine·2023
Same author

Validation of discriminant functions from the rib necks in two Portuguese adult identified populations.

International journal of legal medicine·2023
Same author

Utility of the sternal synostosis for age-at-death estimation in a Mediterranean population.

Forensic science, medicine, and pathology·2022

Related Experiment Video

Updated: Jun 17, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

16.8K

Estimation of the post-mortem interval: a review.

Juan Luis Ruiz López1, Manuel Partido Navadijo1

  • 1Dpto. de Nutrición y Bromatología, Toxicología y Medicina Legal, Área de Medicina Legal y Forense, Universidad de Sevilla, Avda. Dr. Fedriani, s/n, Sevilla 41009, Spain.

Forensic Science International
|February 28, 2025
PubMed
Summary
This summary is machine-generated.

Estimating the time of death, or post-mortem interval (PMI), is crucial in forensic medicine. This review explores traditional and innovative methods for accurate PMI determination, aiding legal investigations.

Keywords:
Forensic MedicineImmunohistochemical methodsPost-mortem intervalProtein degradationReview

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.4K
Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans
12:32

Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans

Published on: September 27, 2020

8.6K

Related Experiment Videos

Last Updated: Jun 17, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

16.8K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.4K
Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans
12:32

Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans

Published on: September 27, 2020

8.6K

Area of Science:

  • Forensic Medicine
  • Legal Medicine
  • Toxicology

Background:

  • Accurate post-mortem interval (PMI) determination is essential for legal and forensic investigations.
  • Estimating PMI becomes more complex as the time since death increases.
  • Traditional methods include assessing body temperature, rigor mortis, and vitreous humor potassium levels.

Purpose of the Study:

  • To provide a comprehensive overview of current post-mortem interval estimation techniques.
  • To serve as a reference guide for understanding recent advancements in PMI determination.
  • To identify limitations of existing methods and explore future research directions.

Main Methods:

  • Review of traditional PMI estimation methods (rigor mortis, body temperature, vitreous potassium).
  • Compilation of innovative methodologies for enhanced PMI prediction.
  • Analysis of the strengths and weaknesses of various PMI determination techniques.

Main Results:

  • Traditional methods offer a baseline for PMI estimation but have limitations.
  • Emerging techniques show potential for increased precision in PMI determination.
  • A critical evaluation of current methodologies is necessary for future advancements.

Conclusions:

  • The field of PMI estimation is evolving with new scientific approaches.
  • Understanding both traditional and novel techniques is vital for forensic practitioners.
  • Further research is needed to refine PMI determination and address existing limitations.