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National investment case development for pathogen genomics.

Yoong Khean Khoo1, Suci Wulandari2, Marya Getchell3

  • 1Centre for Outbreak Preparedness, Duke-NUS Medical School, Singapore, Singapore; SingHealth Duke-NUS Global Health Institute, Duke-NUS Medical School, Singapore, Singapore; Centre of Regulatory Excellence, Duke-NUS Medical School, Singapore, Singapore.

Cell Genomics
|February 28, 2025
PubMed
Summary
This summary is machine-generated.

Investing in genomic surveillance for novel and pandemic pathogens needs better evaluation methods. This study proposes a framework to assess the cost-benefit of multi-pathogen genomic surveillance systems for public health.

Keywords:
disease surveillancegenomicsglobal healthinvestment casenext-generation sequencingpandemic preparednesspathogen genomicssurveillance

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Area of Science:

  • Genomics
  • Epidemiology
  • Public Health

Background:

  • Genomic surveillance is crucial for tracking novel and pandemic pathogens.
  • Current methods lack standardized cost-benefit analyses for multi-pathogen systems.
  • Broader investment in genomics is needed to sustain and expand surveillance capacity.

Purpose of the Study:

  • To propose a standardized framework for evaluating multi-pathogen genomic surveillance systems.
  • To link public health and systems considerations in pathogen surveillance.
  • To provide a stepwise approach for assessing genomic surveillance investments.

Main Methods:

  • Development of a novel framework for pathogen genomic surveillance.
  • Integration of public health and systems considerations.
  • Application of a stepwise approach for evaluation.

Main Results:

  • A proposed framework for cost-benefit analysis of multi-pathogen genomic surveillance.
  • Guidelines for linking public health needs with systems-level planning.
  • A structured approach to investment decisions in genomic surveillance.

Conclusions:

  • The proposed framework offers a standardized methodology for evaluating genomic surveillance.
  • This approach supports informed investment in multi-pathogen surveillance systems.
  • Enhanced genomic surveillance capacity is achievable through systematic evaluation and investment.