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Published on: May 9, 2025
Clinicopathological Features of Diffuse Hemispheric Glioma, H3G34-Mutant
Juan Cao1, Yongxian Chen1, Guocheng Yang1
1Department of Pathology, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, China.
Objective:
To investigate the clinical manifestations, radiographic features, and pathological characteristics of three cases of diffuse hemispheric gliomas, H3G34-mutant (H3G34 DHG).
Methods:
This study used a single-center retrospective cohort approach to analyze 45 pediatric-type diffuse high-grade glioma cases.
Results:
Histologically, case 1 and case 2 had glioblastoma structures, and case 3 had primitive neuroectodermal tumor (PNET) morphology with ganglion cell differentiation. Immunohistochemical staining revealed diffuse expression of H3G34R and P53, but no expression of Olig2, ATRX, IDH1/2 and BRAF V600E in tumor cells in all three cases.
Conclusions:
H3 G34 DHG occurs more significantly in younger patients, and nearly all lesions are located in the cerebral hemisphere. MRI showed mass effects, edema and mild enhancement. The histological type showed glioblastoma structure and PNET morphology. Immunohistochemistry showed that the expression of H3G34R was more significant in PNET morphology.
