Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sex-linked Disorders01:43

Sex-linked Disorders

99.8K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
99.8K
Infertility in Males01:23

Infertility in Males

228
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
228
Epistasis Analysis01:09

Epistasis Analysis

4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
The Y Chromosome Determines Maleness02:19

The Y Chromosome Determines Maleness

6.5K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.5K
Nondisjunction01:21

Nondisjunction

3.7K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting hexokinase 2 for cancer therapy: advances, limitations, and emerging opportunities in inhibitors and degraders.

RSC medicinal chemistry·2026
Same author

Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities.

Acta pharmaceutica Sinica. B·2026
Same author

Antiviral strategies based on targeted protein degradation: An overview of the literature and future outlook.

European journal of medicinal chemistry·2025
Same author

Privileged scaffold repurposed: the evolving role of quinolone derivatives in antiviral therapy.

Bioorganic & medicinal chemistry letters·2025
Same author

Recent research progress of β-carbolines as privileged scaffold in the discovery of anticancer agent (2019-2024).

Bioorganic & medicinal chemistry·2025
Same author

Research progress of active compounds from traditional Chinese medicine in the treatment of stroke.

European journal of medicinal chemistry·2025

Related Experiment Video

Updated: May 24, 2025

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

10.9K

Analysis of genes implicated in non-obstructive azoospermia.

Junwei Wang1, Shuhui Wang2, Meng Wang3

  • 1School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.

Steroids
|February 28, 2025
PubMed
Summary

Gene mutations are a primary cause of non-obstructive azoospermia (NOA), a common infertility factor. Research into these genetic links offers new therapeutic targets for male infertility.

More Related Videos

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

8.1K
Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

8.8K

Related Experiment Videos

Last Updated: May 24, 2025

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

10.9K
Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

8.1K
Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

8.8K

Area of Science:

  • Reproductive Biology
  • Human Genetics
  • Medical Research

Background:

  • Non-obstructive azoospermia (NOA) is the leading cause of male infertility, representing about 60% of azoospermia cases.
  • Gene mutations are increasingly recognized as a significant etiological factor in NOA.
  • Understanding the genetic basis of NOA is crucial for advancing male reproductive health.

Purpose of the Study:

  • To comprehensively review recent advancements in identifying genes associated with non-obstructive azoospermia.
  • To explore the role of gene mutations in the pathogenesis of NOA.
  • To provide a theoretical foundation for developing novel therapeutic strategies for NOA.

Main Methods:

  • Literature review of recent studies on genetic factors in non-obstructive azoospermia.
  • Analysis of genetic alterations in protein-coding regions and non-coding RNAs in NOA patients.
  • Synthesis of current research on gene-environment interactions in male infertility.

Main Results:

  • Gene mutations are concentrated in protein-coding regions and non-coding RNAs in NOA patients.
  • Specific gene mutations are identified as key contributors to the pathogenesis of NOA.
  • The review highlights numerous genes intricately linked to azoospermia development.

Conclusions:

  • Identifying genes associated with NOA provides critical insights into its pathogenesis.
  • Understanding these genetic links can guide the development of targeted therapies for male infertility.
  • This research offers a basis for future therapeutic drug development for NOA.