Transitioning between automated insulin delivery systems: A focus on personalisation

Area of Science:

• Endocrinology
• Metabolic Diseases
• Medical Devices

Background:

• Automated insulin delivery (AID) systems represent the most effective treatment for type 1 diabetes (T1D).
• When glycemic targets are not met, switching between different AID systems is a viable therapeutic option.
• The study investigates the impact of transitioning between AID systems on glucose control and user satisfaction.

Purpose of the Study:

• To assess the effect of switching AID systems on glycemic control in individuals with T1D.
• To evaluate user satisfaction levels after transitioning to a new AID system.
• To determine if glycemic stability is maintained during the adjustment period after switching systems.

Main Methods:

• A multicenter, cross-sectional analysis was performed.
• Included were T1D subjects who had previously switched between AID systems.
• Glycemic control and user satisfaction were assessed before and after the system switch at 14 days and 3 months.

Main Results:

• 96 participants (mean age 40.8 years, 73% female, HbA1c 6.94%) were analyzed.
• Glucose control improved, with Time in Range (70-180 mg/dl) increasing significantly (p < 0.001).
• Most participants reported higher satisfaction, influenced by system size, sensor performance, and algorithm specifics.

Conclusions:

• Transitioning between AID systems can enhance glucose control and user satisfaction.
• Glycemic stability is maintained during the adjustment period when switching AID systems.
• AID system switching offers a promising strategy for optimizing T1D management.